Evolutionary Coupling Analysis
Predicted and experimental contacts
Secondary structure from ECs
Known pdb structures
pdb |
chain |
1b10 |
A |
2kkg |
A |
4yxl |
A |
EC score distribution and threshold
Top ECs
Rank |
Residue 1 |
Amino acid 1 |
Residue 2 |
Amino acid 2 |
EC score |
1 |
189 |
V |
193 |
T |
0.49 |
2 |
185 |
K |
189 |
V |
0.44 |
3 |
212 |
Q |
216 |
T |
0.43 |
4 |
38 |
Y |
42 |
G |
0.42 |
5 |
211 |
E |
219 |
Q |
0.41 |
6 |
200 |
E |
204 |
K |
0.41 |
7 |
43 |
S |
47 |
N |
0.40 |
8 |
44 |
P |
48 |
R |
0.39 |
9 |
217 |
Q |
221 |
E |
0.38 |
10 |
153 |
N |
157 |
Y |
0.37 |
11 |
164 |
R |
170 |
N |
0.37 |
12 |
183 |
T |
187 |
H |
0.36 |
13 |
177 |
H |
185 |
K |
0.36 |
14 |
178 |
D |
182 |
I |
0.36 |
15 |
213 |
M |
221 |
E |
0.35 |
16 |
196 |
E |
200 |
E |
0.35 |
17 |
173 |
N |
177 |
H |
0.35 |
18 |
197 |
N |
201 |
T |
0.35 |
19 |
216 |
T |
220 |
K |
0.35 |
20 |
50 |
P |
54 |
G |
0.34 |
21 |
215 |
T |
219 |
Q |
0.34 |
22 |
74 |
G |
79 |
G |
0.34 |
23 |
210 |
V |
220 |
K |
0.33 |
24 |
187 |
H |
191 |
T |
0.33 |
25 |
187 |
H |
193 |
T |
0.32 |
26 |
176 |
V |
180 |
V |
0.32 |
27 |
140 |
H |
144 |
D |
0.32 |
28 |
59 |
Q |
63 |
G |
0.32 |
29 |
168 |
Q |
172 |
Q |
0.32 |
30 |
199 |
T |
203 |
I |
0.32 |
31 |
172 |
Q |
180 |
V |
0.32 |
32 |
207 |
E |
211 |
E |
0.32 |
33 |
39 |
P |
43 |
S |
0.32 |
34 |
201 |
T |
209 |
V |
0.32 |
35 |
49 |
Y |
53 |
G |
0.32 |
36 |
213 |
M |
217 |
Q |
0.31 |
37 |
36 |
S |
40 |
G |
0.31 |
38 |
200 |
E |
208 |
R |
0.31 |
39 |
143 |
N |
149 |
Y |
0.31 |
40 |
67 |
Q |
71 |
G |
0.31 |
41 |
150 |
Y |
154 |
M |
0.31 |
42 |
42 |
G |
46 |
G |
0.31 |
43 |
95 |
T |
99 |
W |
0.31 |
44 |
106 |
K |
110 |
K |
0.31 |
45 |
148 |
R |
154 |
M |
0.31 |
46 |
147 |
D |
151 |
R |
0.30 |
47 |
61 |
H |
65 |
W |
0.30 |
48 |
96 |
H |
100 |
N |
0.30 |
49 |
186 |
Q |
190 |
T |
0.30 |
50 |
170 |
N |
175 |
F |
0.30 |
51 |
202 |
D |
206 |
M |
0.30 |
52 |
212 |
Q |
220 |
K |
0.30 |
53 |
152 |
E |
156 |
R |
0.29 |
54 |
209 |
V |
223 |
Q |
0.29 |
55 |
35 |
G |
40 |
G |
0.29 |
56 |
150 |
Y |
156 |
R |
0.29 |
57 |
156 |
R |
160 |
Q |
0.29 |
58 |
55 |
G |
59 |
Q |
0.29 |
59 |
74 |
G |
78 |
G |
0.29 |
60 |
180 |
V |
184 |
I |
0.29 |
61 |
143 |
N |
147 |
D |
0.29 |
62 |
165 |
P |
169 |
Y |
0.29 |
63 |
191 |
T |
199 |
T |
0.28 |
64 |
218 |
Y |
224 |
A |
0.28 |
65 |
93 |
G |
97 |
N |
0.28 |
66 |
211 |
E |
217 |
Q |
0.28 |
67 |
139 |
M |
149 |
Y |
0.28 |
68 |
148 |
R |
152 |
E |
0.28 |
69 |
210 |
V |
216 |
T |
0.28 |
70 |
210 |
V |
222 |
S |
0.28 |
71 |
200 |
E |
214 |
C |
0.28 |
72 |
214 |
C |
218 |
Y |
0.27 |
73 |
217 |
Q |
223 |
Q |
0.27 |
74 |
186 |
Q |
192 |
T |
0.27 |
75 |
212 |
Q |
219 |
Q |
0.27 |
76 |
209 |
V |
220 |
K |
0.27 |
77 |
38 |
Y |
48 |
R |
0.27 |
78 |
209 |
V |
215 |
T |
0.27 |
79 |
35 |
G |
39 |
P |
0.27 |
80 |
174 |
N |
182 |
I |
0.27 |
81 |
187 |
H |
192 |
T |
0.27 |
82 |
32 |
N |
38 |
Y |
0.27 |
83 |
212 |
Q |
218 |
Y |
0.27 |
84 |
194 |
K |
202 |
D |
0.27 |
85 |
213 |
M |
222 |
S |
0.27 |
86 |
153 |
N |
158 |
P |
0.27 |
87 |
207 |
E |
213 |
M |
0.27 |
88 |
75 |
Q |
79 |
G |
0.27 |
89 |
146 |
E |
152 |
E |
0.27 |
90 |
208 |
R |
214 |
C |
0.27 |
91 |
208 |
R |
212 |
Q |
0.27 |
92 |
205 |
I |
212 |
Q |
0.27 |
93 |
32 |
N |
36 |
S |
0.26 |
94 |
146 |
E |
150 |
Y |
0.26 |
95 |
195 |
G |
205 |
I |
0.26 |
96 |
182 |
I |
186 |
Q |
0.26 |
97 |
141 |
F |
145 |
W |
0.26 |
98 |
197 |
N |
202 |
D |
0.26 |
99 |
116 |
A |
127 |
G |
0.26 |
100 |
186 |
Q |
191 |
T |
0.26 |
101 |
78 |
G |
82 |
G |
0.26 |
102 |
171 |
N |
181 |
N |
0.26 |
103 |
190 |
T |
194 |
K |
0.26 |
104 |
41 |
Q |
45 |
G |
0.26 |
105 |
33 |
T |
39 |
P |
0.26 |
106 |
190 |
T |
195 |
G |
0.26 |
107 |
204 |
K |
222 |
S |
0.26 |
108 |
214 |
C |
221 |
E |
0.25 |
109 |
206 |
M |
215 |
T |
0.25 |
110 |
210 |
V |
218 |
Y |
0.25 |
111 |
206 |
M |
214 |
C |
0.25 |
112 |
34 |
G |
38 |
Y |
0.25 |
113 |
215 |
T |
221 |
E |
0.25 |
114 |
94 |
G |
98 |
Q |
0.25 |
115 |
53 |
G |
58 |
G |
0.25 |
116 |
199 |
T |
209 |
V |
0.25 |
117 |
130 |
L |
137 |
P |
0.25 |
118 |
58 |
G |
64 |
G |
0.25 |
119 |
207 |
E |
217 |
Q |
0.25 |
120 |
118 |
A |
122 |
V |
0.25 |
121 |
176 |
V |
181 |
N |
0.25 |
122 |
103 |
S |
107 |
T |
0.25 |
123 |
170 |
N |
174 |
N |
0.25 |
124 |
94 |
G |
100 |
N |
0.25 |
125 |
206 |
M |
211 |
E |
0.25 |
126 |
183 |
T |
188 |
T |
0.25 |
127 |
40 |
G |
48 |
R |
0.25 |
128 |
171 |
N |
175 |
F |
0.25 |
129 |
191 |
T |
198 |
F |
0.25 |
130 |
199 |
T |
205 |
I |
0.25 |
131 |
132 |
S |
136 |
R |
0.25 |
132 |
210 |
V |
214 |
C |
0.25 |
133 |
208 |
R |
224 |
A |
0.25 |
134 |
201 |
T |
219 |
Q |
0.24 |
135 |
220 |
K |
224 |
A |
0.24 |
136 |
79 |
G |
83 |
Q |
0.24 |
137 |
76 |
P |
80 |
G |
0.24 |
138 |
42 |
G |
52 |
Q |
0.24 |
139 |
113 |
A |
117 |
A |
0.24 |
140 |
213 |
M |
219 |
Q |
0.24 |
141 |
56 |
T |
62 |
G |
0.24 |
142 |
57 |
W |
63 |
G |
0.24 |
143 |
77 |
H |
81 |
W |
0.24 |
144 |
203 |
I |
207 |
E |
0.24 |
145 |
109 |
M |
113 |
A |
0.24 |
146 |
192 |
T |
201 |
T |
0.24 |
147 |
219 |
Q |
223 |
Q |
0.24 |
148 |
143 |
N |
153 |
N |
0.24 |
149 |
204 |
K |
211 |
E |
0.24 |
150 |
169 |
Y |
173 |
N |
0.24 |
151 |
3 |
N |
32 |
N |
0.24 |
152 |
212 |
Q |
224 |
A |
0.24 |
153 |
215 |
T |
222 |
S |
0.24 |
154 |
206 |
M |
210 |
V |
0.24 |
155 |
166 |
V |
170 |
N |
0.24 |
156 |
131 |
G |
135 |
S |
0.24 |
157 |
142 |
G |
150 |
Y |
0.24 |
158 |
145 |
W |
149 |
Y |
0.24 |
159 |
204 |
K |
208 |
R |
0.23 |
160 |
164 |
R |
168 |
Q |
0.23 |
161 |
63 |
G |
69 |
H |
0.23 |
162 |
202 |
D |
207 |
E |
0.23 |
163 |
165 |
P |
176 |
V |
0.23 |
164 |
177 |
H |
181 |
N |
0.23 |
165 |
211 |
E |
221 |
E |
0.23 |
166 |
208 |
R |
217 |
Q |
0.23 |
167 |
107 |
T |
111 |
H |
0.23 |
168 |
208 |
R |
220 |
K |
0.23 |
169 |
193 |
T |
201 |
T |
0.23 |
170 |
211 |
E |
215 |
T |
0.23 |
171 |
114 |
G |
121 |
V |
0.23 |
172 |
206 |
M |
224 |
A |
0.23 |
173 |
185 |
K |
191 |
T |
0.23 |
174 |
208 |
R |
213 |
M |
0.23 |
175 |
214 |
C |
223 |
Q |
0.23 |
176 |
209 |
V |
222 |
S |
0.23 |
177 |
163 |
Y |
173 |
N |
0.23 |
178 |
209 |
V |
214 |
C |
0.23 |
179 |
179 |
C |
183 |
T |
0.23 |
180 |
149 |
Y |
153 |
N |
0.23 |
181 |
215 |
T |
223 |
Q |
0.23 |
182 |
190 |
T |
196 |
E |
0.23 |
183 |
196 |
E |
202 |
D |
0.23 |
184 |
193 |
T |
203 |
I |
0.23 |
185 |
37 |
R |
48 |
R |
0.23 |
186 |
215 |
T |
220 |
K |
0.23 |
187 |
151 |
R |
158 |
P |
0.23 |
188 |
207 |
E |
214 |
C |
0.23 |
189 |
209 |
V |
213 |
M |
0.22 |
190 |
197 |
N |
205 |
I |
0.22 |
191 |
182 |
I |
188 |
T |
0.22 |
192 |
121 |
V |
125 |
L |
0.22 |
193 |
36 |
S |
46 |
G |
0.22 |
194 |
183 |
T |
191 |
T |
0.22 |
195 |
189 |
V |
195 |
G |
0.22 |
196 |
173 |
N |
178 |
D |
0.22 |
197 |
211 |
E |
220 |
K |
0.22 |
198 |
206 |
M |
213 |
M |
0.22 |
199 |
196 |
E |
201 |
T |
0.22 |
200 |
207 |
E |
221 |
E |
0.22 |
201 |
144 |
D |
148 |
R |
0.22 |
202 |
218 |
Y |
222 |
S |
0.22 |
203 |
194 |
K |
205 |
I |
0.22 |
204 |
47 |
N |
51 |
P |
0.22 |
205 |
208 |
R |
215 |
T |
0.22 |
206 |
94 |
G |
101 |
K |
0.22 |
207 |
111 |
H |
116 |
A |
0.22 |
208 |
182 |
I |
191 |
T |
0.22 |
209 |
168 |
Q |
174 |
N |
0.22 |
210 |
56 |
T |
64 |
G |
0.22 |
211 |
172 |
Q |
176 |
V |
0.22 |
212 |
110 |
K |
116 |
A |
0.22 |
213 |
197 |
N |
209 |
V |
0.22 |
214 |
128 |
Y |
134 |
M |
0.22 |
215 |
187 |
H |
195 |
G |
0.22 |
216 |
201 |
T |
205 |
I |
0.22 |
217 |
129 |
M |
133 |
A |
0.22 |
218 |
94 |
G |
99 |
W |
0.22 |
219 |
209 |
V |
218 |
Y |
0.22 |
220 |
65 |
W |
71 |
G |
0.22 |
221 |
205 |
I |
222 |
S |
0.22 |
222 |
195 |
G |
203 |
I |
0.22 |
223 |
41 |
Q |
70 |
G |
0.22 |
224 |
152 |
E |
158 |
P |
0.22 |
225 |
183 |
T |
189 |
V |
0.22 |
226 |
198 |
F |
203 |
I |
0.21 |
227 |
80 |
G |
84 |
P |
0.21 |
228 |
196 |
E |
207 |
E |
0.21 |
229 |
195 |
G |
199 |
T |
0.21 |
230 |
209 |
V |
217 |
Q |
0.21 |
231 |
105 |
P |
109 |
M |
0.21 |
232 |
204 |
K |
215 |
T |
0.21 |
233 |
214 |
C |
224 |
A |
0.21 |
234 |
175 |
F |
181 |
N |
0.21 |
235 |
202 |
D |
212 |
Q |
0.21 |
236 |
167 |
D |
175 |
F |
0.21 |
237 |
210 |
V |
224 |
A |
0.21 |
238 |
197 |
N |
215 |
T |
0.21 |
239 |
210 |
V |
219 |
Q |
0.21 |
240 |
203 |
I |
213 |
M |
0.21 |
241 |
38 |
Y |
43 |
S |
0.21 |
242 |
38 |
Y |
44 |
P |
0.21 |
243 |
61 |
H |
66 |
G |
0.21 |
244 |
174 |
N |
178 |
D |
0.21 |
245 |
193 |
T |
197 |
N |
0.21 |
246 |
213 |
M |
223 |
Q |
0.21 |
247 |
151 |
R |
157 |
Y |
0.21 |
248 |
181 |
N |
192 |
T |
0.21 |
249 |
172 |
Q |
178 |
D |
0.21 |
250 |
200 |
E |
205 |
I |
0.21 |
251 |
115 |
A |
123 |
G |
0.21 |
252 |
145 |
W |
151 |
R |
0.21 |
253 |
139 |
M |
144 |
D |
0.21 |
254 |
165 |
P |
170 |
N |
0.21 |
255 |
1 |
M |
34 |
G |
0.21 |
256 |
181 |
N |
185 |
K |
0.21 |
257 |
167 |
D |
171 |
N |
0.21 |
258 |
32 |
N |
39 |
P |
0.21 |
259 |
171 |
N |
187 |
H |
0.21 |
260 |
214 |
C |
222 |
S |
0.21 |
261 |
139 |
M |
152 |
E |
0.21 |
Alignment robustness analysis
First most common residue correlation
Second most common residue correlation